If a mother or father in the proband is known to have the pathogenic variant determined while in the proband, the danger to the sibs of inheriting the pathogenic variant is 50%. Because of lessened penetrance, sibs who inherit the pathogenic variant may or may not build aHUS (see Penetrance). https://sap-ewm98764.therainblog.com/31253011/helping-the-others-realize-the-advantages-of-air-handling-unit-ahu-hire