You will find a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to decrease afferent pain transmission and develop analgesia. For that reason, medications like clonidine that concentrate on alpha-two receptors can affect the transmission of pain. Applies to clonidine: https://rylanhasiw.activoblog.com/33936578/top-latest-five-onolidine-urban-news