Four.4 Unique warnings and safeguards for use Tolerance and Opioid Use Problem (abuse and dependence) Tolerance, Actual physical and psychological dependence, and opioid use dysfunction (OUD) could acquire on recurring administration of opioids. Abuse or intentional misuse of opioids may cause overdose and/or death. The chance of establishing OUD is https://steelet122pcp7.wikilinksnews.com/user